The Middle Deschutes is fishing well from Bend down to Lake Billy Chinook. There are pockets of good caddis hatches, and pockets of better mayfly areas and places where you might enjoy both. 
Look for tiny BWO’s in a #22, but more PMD #16 and PED’s in #14 or maybe a #12. Caddis are a mix of tan #16, olive #16-18 and dark brown #18 and look for some yellow sally stones, more in the afternoon and early evening. 
A lot of time I spend on the middle river I use a renegade or purple haze. To get a little more match the hatch specific add some X caddis, sparkle duns and soft hackles. 
Nymphing is always an option and is especially good with brown perdigons, PT soft hackles, caddis pupa, micro may’s and some small streamers like mini gulps, sculpzilla and squirrel leeches.