The Middle Deschutes is awesome and close to home. The best times are 6 am to noon and 6 pm to dark. I like to carry my Echo Shadow X 10′ 3wt and fish nymphs on a Mono-Rig until dry fly action is prevalent, and then switch to a Yellow Sparkle Dun and Purple Haze when the fish are looking up. Keep an eye out closely for smaller Blue Wing Olives in the evening as they can be overlooked when larger yellow mayflies are masking the other hatch. Caddis in many areas of the middle river will be important and there is no better Middle D caddis than an X Caddis in Tan #14-16 or Olive #16. Of course we love a lot of caddis dries here, but going out on a limb, over the years the X Caddis is usually the most consistent for the middle D. Euro Jig Streamers never hurt anyone looking to add quality over quantity to their session. Do you tie flies? Try a #16 nymph hook (not a jig) and add a 2 to 3mm anodized light pink bead, CDL tail, Tan Hends Buzzer Body or Veevus Body Quill and a Hot Orange Hot Spot. Coat it all with a Clear UV Resin and Add a Black UV Resin for the Wingcase. This is my #1 Middle D Perdigon.